abstract：BACKGROUND:Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship bet...

journal_title：Journal of ovarian research

authors： Zhang R,Shi H,Ren F,Zhang M,Ji P,Wang W,Liu C

更新日期：2017-09-12 00:00:00

abstract：:As the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a...

journal_title：Journal of ovarian research

authors： Freitas C,Neto AC,Matos L,Silva E,Ribeiro Â,Silva-Carvalho JL,Almeida H

更新日期：2017-07-12 00:00:00

abstract：:We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and re...

journal_title：Journal of ovarian research

authors： Bhartiya D,James K

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:Mature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary. The aim of this study is to clarify if development of mature cystic teratomas of the ovaries in a single host is metachronous or due to autoimplant or ...

journal_title：Journal of ovarian research

authors： Wang WC,Lai YC

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:The mechanism of aggressive character of ovarian cancer and unsuccessful treatment of women with this deadly disease has been recently explained by the theory of cancer stem cells (CSCs). It has been reported that ovarian carcinogenesis and progression of disease is associated with epithelial-mesenchymal tra...

journal_title：Journal of ovarian research

authors： Kenda Suster N,Smrkolj S,Virant-Klun I

更新日期：2017-02-23 00:00:00

abstract：BACKGROUND:Recent researches demonstrate that pre-treatment with androgen could increase retrieved oocytes number and clinical pregnancy rate in poor ovarian response (POR) patients. In view of gap junction intercellular communication (GJIC) is important for follicular growth, and androgen plays an important role in im...

journal_title：Journal of ovarian research

authors： Zhang Y,Xu Y,Kuai Y,Wang S,Xue Q,Shang J

更新日期：2016-11-23 00:00:00

abstract：BACKGROUND:Ovarian thecoma-fibroma groups (OTFG) are uncommon sex cord-stromal neoplasms. The objective of the study was to demonstrate clinical and sonographic features of OTFG and compare with surgical histopathology. METHODS:A total of 61 patients with surgically proven OTFG were enrolled in this retrospective stud...

journal_title：Journal of ovarian research

authors： Chen H,Liu Y,Shen LF,Jiang MJ,Yang ZF,Fang GP

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS:We determined the expression of SNAP23 in OC tissues and explored the clinical signifi...

journal_title：Journal of ovarian research

authors： Sun Q,Huang X,Zhang Q,Qu J,Shen Y,Wang X,Sun H,Wang J,Xu L,Chen X,Ren B

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonst...

journal_title：Journal of ovarian research

authors： Thomas ED,Meza-Perez S,Bevis KS,Randall TD,Gillespie GY,Langford C,Alvarez RD

更新日期：2016-10-27 00:00:00

abstract：BACKGROUND:The mechanisms regulating the function and regression of the corpus luteum (CL) have not yet been elucidated in detail. The regressed CL of cows was previously reported to be filled with unusual vessels like arteriovenous anastomosis (AVA); however how these vessels are being established during luteolysis re...

journal_title：Journal of ovarian research

authors： Nio-Kobayashi J,Miyazaki K,Hashiba K,Okuda K,Iwanaga T

更新日期：2016-10-19 00:00:00

abstract：BACKGROUND:Because higher survival of follicles during the freezing/thawing procedure improves the quality of cryopreserved tissue reimplanted after oncological therapies, defining an optimal method for human ovarian tissue cryopreservation remains a major issue in this field. One option to improve the cryopreservation...

journal_title：Journal of ovarian research

authors： Scheiner D,Bracone G,Imesch P,Fink D,Hehl J,Imthurn B

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Experience on sentinel node mapping in ovarian tumors is very limited. We evaluated the sentinel node concept in ovarian tumors using intra-operativeTc-99m-Phytate injection and lymphoscintigraphy imaging. METHODS:Thirty-five patients with a pelvic mass due to an ovarian pathology were included in the study...

journal_title：Journal of ovarian research

authors： Hassanzadeh M,Hosseini Farahabadi E,Yousefi Z,Kadkhodayan S,Zarifmahmoudi L,Sadeghi R

更新日期：2016-09-07 00:00:00

abstract：BACKGROUND:This study was aimed to explore the role of long noncoding RNA C17orf91 and its potential mechanisms in ovarian cancer development. RESULTS:To assess its role in ovarian cancer, microarray datasets (GSE14407, GSE30587, and GSE17260) in Gene Expression Omnibus (GEO) were utilized to assess the expression and...

journal_title：Journal of ovarian research

authors： Li J,Yu H,Xi M,Lu X

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Cell lines are very useful for both clinical and basic research. The establishment of ovarian, malignant tumor cell lines with aggressive histology is especially important. We describe the establishment and characterization of a new human clear cell carcinoma cell line of the ovary. RESULTS:The cell line HC...

journal_title：Journal of ovarian research

authors： Yamada T,Hattori K,Satomi H,Okazaki T,Mori H,Hirose Y

更新日期：2016-06-04 00:00:00

abstract：:High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high responsiveness to platinum-based-chemotherapy. To date, standard first-line-chemotherapy in advanced EOC include...

journal_title：Journal of ovarian research

authors： Mignogna C,Staropoli N,Botta C,De Marco C,Rizzuto A,Morelli M,Di Cello A,Franco R,Camastra C,Presta I,Malara N,Salvino A,Tassone P,Tagliaferri P,Barni T,Donato G,Di Vito A

更新日期：2016-05-21 00:00:00

abstract：BACKGROUND:The down-regulation of E-cadherin gene (CDH1) expression has been regarded as an important event in cancer invasion and metastasis. However, the association between CDH1 promoter methylation and ovarian cancer remains unclear. A meta-analysis was conducted to evaluate the potential role of CDH1 promoter meth...

journal_title：Journal of ovarian research

authors： Wang Q,Wang B,Zhang YM,Wang W

更新日期：2016-04-11 00:00:00

abstract：BACKGROUND:Ovarian cancer (OVC) is the deadliest of all gynecologic cancers, primarily as a consequence of asymptomatic progression. The complex nature of OVC creates challenges for early detection, and there is a lack of specific and sensitive biomarkers suitable for screening and detecting early stage OVC. METHODS:P...

journal_title：Journal of ovarian research

authors： Tamir A,Gangadharan A,Balwani S,Tanaka T,Patel U,Hassan A,Benke S,Agas A,D'Agostino J,Shin D,Yoon S,Goy A,Pecora A,Suh KS

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Recent studies have shown that microRNAs may regulate the ABCB1 gene (ATP-binding cassette, sub-family B [MDR/TAP], member 1). Computational programs have predicted that the 3'-untranslated region (3'-UTR) of ABCB1 contains a potential miRNA-binding site for miR-186. Here, we investigated the role of miR-186...

journal_title：Journal of ovarian research

authors： Sun KX,Jiao JW,Chen S,Liu BL,Zhao Y

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:galectin-1 has been implicated in tumor invasion and metastasis and is frequently over-expressed in epithelial ovarian cancer (EOC), but its potential as a biomarker remains unclear. In this novel study, we have explored the possible use of galectin-1 as a biomarker for EOC. METHODS:galectin-1 in sera was e...

journal_title：Journal of ovarian research

authors： Chen L,Yao Y,Sun L,Zhou J,Liu J,Wang J,Li J,Tang J

更新日期：2015-11-21 00:00:00

abstract：BACKGROUND:Metformin decreases polycystic ovary syndrome (PCOS) symptoms, induces ovulation, and may improve developmental competence of in vitro oocyte maturation. This study was designed to define the effects of metformin on the characteristics of in vitro oocyte maturation in estradiol valerate (EV) PCOS-induced rat...

journal_title：Journal of ovarian research

authors： Mesbah F,Moslem M,Vojdani Z,Mirkhani H

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Polycystic Ovary Syndrome (PCOS) is a widespread reproductive disorder characterized by a disruption of follicular growth and anovulatory infertility. In women with PCOS, follicular growth and ovulation can be induced by subcutaneous injections of low doses of follicle stimulating hormone (FSH). The aim of t...

journal_title：Journal of ovarian research

authors： Tessaro I,Modina SC,Franciosi F,Sivelli G,Terzaghi L,Lodde V,Luciano AM

更新日期：2015-10-06 00:00:00

abstract：:Both estrogens and androgens are involved in the development and normal functioning of the ovaries. It is also known that ovarian function is regulated by diet. The goal of this study was to estimate the expression of sex hormone receptors in ovaries of mice that were on a 9-month caloric restriction (alternate-day fe...

journal_title：Journal of ovarian research

authors： Słuczanowska-Głąbowska S,Laszczyńska M,Piotrowska K,Grabowska M,Grymuła K,Ratajczak MZ

更新日期：2015-08-13 00:00:00

abstract：:Infertility is a medical and social condition that affects millions of women worldwide and is today considered so far as a new disease. A considerable progress has been recently pursued in the field of the reproductive medicine and the infertility treatment may account for novel and modern procedures such as in vitro ...

journal_title：Journal of ovarian research

authors： Silvestris E,D'Oronzo S,Cafforio P,D'Amato G,Loverro G

更新日期：2015-08-07 00:00:00

abstract：BACKGROUND:Mucinous carcinomas from different organs are morphologically similar and might share similarities at the molecular and biochemical levels that may illuminate their pathogenesis and influence management. The factors involved in the pathogenesis of mucinous carcinomas remain unknown; which is likely one contr...

journal_title：Journal of ovarian research

authors： Desouki MM,Franklin RB,Costello LC,Fadare O

更新日期：2015-06-17 00:00:00

abstract：BACKGROUND:We aimed to examine the expression of miR-1307 in chemosensitive and chemoresistant epithelial ovarian cancer tissues and cell lines and to analyze the clinicopathological significance of miR-1307 in ovarian cancer. METHODS:MicroRNA microarray was used to screen differentially expressed microRNAs between th...

journal_title：Journal of ovarian research

authors： Zhou Y,Wang M,Wu J,Jie Z,Chang S,Shuang T

更新日期：2015-04-09 00:00:00

abstract：:The Publisher and Editor regretfully retract this article ( Hou W, Guan J, Lu H, Dong Q, Han Y, Zhang R. The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induced by paclitaxel. J Ovarian Res. 2014;7:89) because the peer-review process was inappropriately influenced and comp...

journal_title：Journal of ovarian research

authors：

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Hypertensive disorders of pregnancy are the most common causes of adverse maternal & perinatal outcomes. Such investigations in resource limited settings would help to have great design strategies in preventing maternal and perinatal morbidity and mortality. AIM:To determine management outcome and factor as...

journal_title：Journal of ovarian research

authors： Seyom E,Abera M,Tesfaye M,Fentahun N

更新日期：2015-03-15 00:00:00

abstract：PURPOSE:The conversion of androgens into estrogens by aromatase is called aromatization and is inhibited by aromatase inhibitors (AIs). The aim of this article is to evaluate the use of aromatase inhibitors in gynecological diseases such as endometriosis, leiomyoma, estrogen- dependent gynecologic neoplasia and inferti...

journal_title：Journal of ovarian research

authors： Usluogullari B,Duvan C,Usluogullari C

更新日期：2015-02-25 00:00:00

abstract：:Mixed germ cell tumours of the ovary are malignant neoplasms of the ovary comprising of two or more types of germ cell components. Most of the malignant mixed germ cell tumours consists of dysgerminoma accompanied by endodermal sinus tumours, immature teratoma or choriocarcinoma. There are only few case reports of mix...

journal_title：Journal of ovarian research

authors： Goyal LD,Kaur S,Kawatra K

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women. Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats. The aim of the present study is to explore the effect of SIRT1 acti...

journal_title：Journal of ovarian research

authors： Zhou XL,Xu JJ,Ni YH,Chen XC,Zhang HX,Zhang XM,Liu WJ,Luo LL,Fu YC

更新日期：2014-10-21 00:00:00

abstract：BACKGROUND:Pelvic irradiation is essential for improving survival in women with pelvic malignancies despite inducing permanent ovarian damage. Ovarian transposition can be performed in premenopausal women in an attempt to preserve ovarian function. As uncertainty occurs over the proportion of women who are likely to be...

journal_title：Journal of ovarian research

authors： Gubbala K,Laios A,Gallos I,Pathiraja P,Haldar K,Ind T

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:Our recent study on a panel of human ovarian cancer cells revealed that SKOV-3 cells barely express the Sprouty isoform 1 (Spry1) while 1A9 cells maintain it at a level similar to normal ovarian cells. Here we investigated the functional outcomes of induced alterations in the expression of Spry1 in the two c...

journal_title：Journal of ovarian research

authors： Masoumi-Moghaddam S,Amini A,Ehteda A,Wei AQ,Morris DL

更新日期：2014-06-08 00:00:00

abstract：:Ovarian cancer is the fifth most common cause of cancer death in women and the leading cause of death from gynaecological malignancies. Of the 75% women diagnosed with locally advanced or disseminated disease, only 30% will survive five years following treatment. This poor prognosis is due to the following reasons: li...

journal_title：Journal of ovarian research

authors： Jacob F,Nixdorf S,Hacker NF,Heinzelmann-Schwarz VA

更新日期：2014-06-07 00:00:00

abstract：BACKGROUND:The objective of this study was to build the transcriptomic profile of granulosa cells originating from follicles 6 to 9 mm in diameter in dairy cattle using microarrays. METHODS:Granulosa cells originating from three different phases of antral follicle growth were compared: growing (G), plateau (P) and atr...

journal_title：Journal of ovarian research

authors： Douville G,Sirard MA

更新日期：2014-05-07 00:00:00

abstract：BACKGROUND:Studies on the association between obesity and ovarian cancer survival have had conflicting results. We reviewed and quantitatively summarized the existing evidence, exploring potentially important sources of variability, such as the timing of body mass index (BMI) assessment, BMI cut points, references used...

journal_title：Journal of ovarian research

authors： Bae HS,Kim HJ,Hong JH,Lee JK,Lee NW,Song JY

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Hyaluronic acid is a prognostic factor in ovarian cancers. It is also a component of Hyaluronic Acid-Carboxymethyl Cellulose (HA-CMC) barrier, an anti-adhesion membrane widely used during abdominal surgeries in particular for ovarian carcinosis. 70% of patients who undergo ovarian surgery will relapse due to...

journal_title：Journal of ovarian research

authors： Picaud L,Thibault B,Mery E,Ouali M,Martinez A,Delord JP,Couderc B,Ferron G

更新日期：2014-04-16 00:00:00

abstract：INTRODUCTION:Weight gain and fat accumulation are predisposing factors of PCOS. Life-style modification, including increasing physical activity, is the first line approach in managing PCOS. The objective of this study is to assess the effect of exercise intensity on weight changes, androstenedione and free testosterone...

journal_title：Journal of ovarian research

authors： Miri M,Karimi Jashni H,Alipour F

更新日期：2014-04-08 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the concentrations of IgG antibodies against Hsp60 and Hsp65 in sera of patients with ovarian cancer at various stages of clinical progress and for different histopathological types of disease. METHODS:Serum samples from 149 patients with ovarian carcinoma and 80 health...

journal_title：Journal of ovarian research

authors： Bodzek P,Partyka R,Damasiewicz-Bodzek A

更新日期：2014-03-11 00:00:00

abstract：BACKGROUND:Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to insulin resistance (IR) in these women. However, studies on the role of adiponectin in ...

journal_title：Journal of ovarian research

authors： Mirza SS,Shafique K,Shaikh AR,Khan NA,Anwar Qureshi M

更新日期：2014-02-07 00:00:00

abstract：BACKGROUND:Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascularization includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood ves...

journal_title：Journal of ovarian research

authors： Kizuka-Shibuya F,Tokuda N,Takagi K,Adachi Y,Lee L,Tamura I,Maekawa R,Tamura H,Suzuki T,Owada Y,Sugino N

更新日期：2014-01-21 00:00:00